Article

Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model of <i>GCK</i> -MODY

2024-11-11

Abstract excerpt

Glucokinase (GK) catalyses the key regulatory step in glucose-stimulated insulin secretion. Correspondingly, hetero– and homozygous mutations in human GCK cause maturity-onset diabetes of the young (GCK-MODY) and permanent neonatal diabetes (PNDM), respectively. To explore the possible utility of glucokinase activators (GKA) and of glucagon–like receptor-1 (GLP-1) agonists in these diseases, we have developed a n...

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Literature Corpus work: 44b8b7cd-77cd-524d-a77b-82fbae17246f
DOI: 10.1101/2024.11.09.622781

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