Article

Insulin resistance-driven beta-cell adaptation in mice: Mechanistic characterization and 3D analysis

2023-01-09

Abstract excerpt

<h4>Aims/hypothesis</h4> Pancreatic beta cells secrete insulin to control glucose homeostasis. Beta cells can also adapt their function and mass when more insulin is required, especially in situations of insulin resistance (IR). Beta-cell mass adaptation can be achieved through either beta-cell proliferation or beta-cell neogenesis, a process that involves de novo beta-cell production from precursor cells. Signal...

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Literature Corpus work: 33e17586-c35b-5c8f-a8a4-c3fc32a8f134
DOI: 10.1101/2023.01.09.523222

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