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Article

Selectively Bred Diabetes Models: GK Rats, NSY Mice, and ON Mice.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Nagao Mototsugu, Esguerra Jonathan Lou S, Wendt Anna, Asai Akira, Sugihara Hitoshi, Oikawa Shinichi, Eliasson Lena

Abstract excerpt

The polygenic background of selectively bred diabetes models mimics the etiology of type 2 diabetes. So far, three different rodent models (Goto-Kakizaki rats, Nagoya-Shibata-Yasuda mice, and Oikawa-Nagao mice) have been established in the diabetes research field by continuous selective breeding for glucose tolerance from outbred rodent stocks. The origin of hyperglycemia in these rodents is mainly insulin...

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PMID: 32180184
DOI: 10.1007/978-1-0716-0385-7_3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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