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Article

Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine.

Gastroenterology - 1 Oct 2018

Petersen Natalia, Frimurer Thomas M, Terndrup Pedersen Marianne, Egerod Kristoffer L, Wewer Albrechtsen Nicolai J, Holst Jens J, Grapin-Botton Anne, Jensen Kim B, Schwartz Thue W

Abstract excerpt

BACKGROUND & AIMS: Glucagon-like peptide 1 (GLP1) is produced by L cells in the intestine, and agonists of the GLP1 receptor are effective in the treatment of diabetes. Levels of GLP1 increase with numbers of L cells. Therefore, agents that increase numbers of L cell might be developed for treatment of diabetes. Ras homologue family member A (RhoA) signaling through Rho-associated coiled-coil-containing protein...

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Source

Identifiers

PMID: 29935151
DOI: 10.1053/j.gastro.2018.06.039

Genes

ROCK1
ROCK2
RHOA

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