Article
Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2.
Hepatology (Baltimore, Md.) - 1 Apr 2002
Baffy György, Zhang Chen-Yu, Glickman Jonathan N, Lowell Bradford B
Abstract excerpt
Nonalcoholic fatty liver disease (NAFLD), a prevalent condition associated with obesity, has the potential of evolving into end-stage liver disease. The biochemical mechanisms that define the progression of NAFLD are not well known, but reactive oxygen species (ROS) have been implicated in this process. Uncoupling protein (UCP) 2 is a mitochondrial inner-membrane protein that mediates proton leak, uncouples...
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