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Article

UCP2 Knockout Suppresses Mouse Skin Carcinogenesis

17 Mar 2015

Abstract excerpt

Mitochondrial uncoupling (uncouples electron transport from ATP production) has recently been proposed as a novel survival mechanism for cancer cells, and reduction in free radical generation is the accepted mechanism of action. However, there is no direct evidence supporting that uncoupling proteins promote carcinogenesis. Herein, we examined whether mitochondrial uncoupling affects mouse skin carcinogenesis...

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PMID: 25784177
DOI: 10.1158/1940-6207.capr-14-0297-t

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