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Article

Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant.

The Journal of experimental medicine - 16 Apr 2001

Friedman J S, Rebel V I, Derby R, Bell K, Huang T T, Kuypers F A, Epstein C J, Burakoff S J

Abstract excerpt

Manganese superoxide dismutase 2 (SOD2) is a critical component of the mitochondrial pathway for detoxification of O2(-), and targeted disruption of this locus leads to embryonic or neonatal lethality in mice. To follow the effects of SOD2 deficiency in cells over a longer time course, we created hematopoietic chimeras in which all blood cells are derived from fetal liver stem cells of Sod2 knockout,...

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Source

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Identifiers

PMID: 11304553
DOI: 10.1084/jem.193.8.925
PMCID: PMC2193409

Genes

SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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