Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New aspects of mitochondrial Uncoupling Proteins (UCPs) and their roles in tumorigenesis.

International journal of molecular sciences - 1 Jan 2011

Robbins Delira, Zhao Yunfeng

Abstract excerpt

Uncoupling proteins (UCPs) belong to a family of mitochondrial carrier proteins that are present in the mitochondrial inner membrane. UCP1 was first identified followed by its two homologs, UCP2 and UCP3. The physiological functions of UCP include lowering mitochondrial membrane potential and dissipating metabolic energy as heat. However, UCP can be dysregulated and may contribute to the pathogenesis of metabolic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Ion Channels

Share to Mitochondria

Share to Mitochondrial Proteins

Share to Tumor Suppressor Protein p53

Share to Uncoupling Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 21954358
DOI: 10.3390/ijms12085285
PMCID: PMC3179165

Genes

UCP2
UCP1
UCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New aspects of mitochondrial Uncoupling Proteins (UCPs) and their roles in tumorigenesis.PMID 21954358Read ↗

UCP2 as a Cancer Target through Energy Metabolism and Oxidative Stress ControlSemantic proximity Read ↗

UCP 2 gene polymorphisms in obesity and diabetes, and the role of UCP 2 in cancerSemantic proximity Read ↗

The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes.Semantic proximity Read ↗

Differential regulation of mitochondrial uncoupling protein 2 in cancer cellsSemantic proximity Read ↗

Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.Semantic proximity Read ↗

UCP2, a mitochondrial protein regulated at multiple levels.Semantic proximity Read ↗

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases.Semantic proximity Read ↗

The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus.Semantic proximity Read ↗

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes.Semantic proximity Read ↗

Uncoupling Protein 2, in Vivo Distribution, Induction upon Oxidative Stress, and Evidence for Translational RegulationSemantic proximity Read ↗

UCP2 45bp Ins/Del gene polymorphism in association with overweight and obesity: a meta-analysisSemantic proximity Read ↗

Associations between polymorphisms in the mitochondrial uncoupling proteins (UCPs) with T2DM.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.