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Article

Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production.

The Journal of biological chemistry - 13 May 2005

Bai Yushi, Onuma Hiroki, Bai Xu, Medvedev Alexander V, Misukonis Mary, Weinberg J Brice, Cao Wenhong, Robidoux Jacques, Floering Lisa M, Daniel Kiefer W, Collins Sheila

Abstract excerpt

One of the phenotypes of mice with targeted disruption of the uncoupling protein-2 gene (Ucp2-/-) is greater macrophage phagocytic activity and free radical production, resulting in a striking resistance to infectious microorganisms. In this study, the molecular mechanisms of this enhanced immune response were investigated. We found that levels of nitric oxide measured in either plasma or isolated macrophages...

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Identifiers

PMID: 15757894
DOI: 10.1074/jbc.M500566200
PMCID: PMC1382174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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