Article
Anion Transport or Nucleotide Binding by Ucp2 Is Indispensable for Ucp2-Mediated Efferocytosis.
Molecules and cells - 1 Jul 2015
Lee Suho, Moon Hyunji, Kim Gayoung, Cho Jeong Hoon, Lee Dae-Hee, Dae-Hee Lee, Ye Michael B, Park Daeho
Abstract excerpt
Rapid and efficient engulfment of apoptotic cells is an essential property of phagocytes for removal of the large number of apoptotic cells generated in multicellular organisms. To achieve this, phagocytes need to be able to continuously uptake apoptotic cells. It was recently reported that uncoupling protein 2 (Ucp2) promotes engulfment of apoptotic cells by increasing the phagocytic capacity, thereby allowing...
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