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Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APP <sub>Sw,Ind</sub> ) mice

30 Aug 2004

Abstract excerpt

Neurogenesis continues in the adult brain and is increased in certain pathological states. We reported recently that neurogenesis is enhanced in hippocampus of patients with Alzheimer's disease (AD). We now report that the effect of AD on neurogenesis can be reproduced in a transgenic mouse model. PDGF-APP(Sw,Ind) mice, which express the Swedish and Indiana amyloid precursor protein mutations, show increased...

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PMID: 15340159
DOI: 10.1073/pnas.0403678101

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