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Article

The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging.

The Journal of investigative dermatology - 1 Nov 2016

Ghosh Kanad, Capell Brian C

Abstract excerpt

Cellular senescence, a state of stable cell cycle arrest in response to cellular stress, is an indispensable mechanism to counter tumorigenesis by halting the proliferation of damaged cells. However, through the secretion of an array of diverse cytokines, chemokines, growth factors, and proteases known as the senescence-associated secretory phenotype (SASP), senescent cells can paradoxically promote...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27543988
DOI: 10.1016/j.jid.2016.06.621
PMCID: PMC5526201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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