Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases

21 Dec 2020

Abstract excerpt

Cellular senescence represents a robust tumor-protecting mechanism that halts the proliferation of stressed or premalignant cells. However, this state of stable proliferative arrest is accompanied by the Senescence-Associated Secretory Phenotype (SASP), which entails the copious secretion of proinflammatory signals in the tissue microenvironment and contributes to age-related conditions, including, paradoxically,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune cells in cancer
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33371508
DOI: 10.3390/biology9120485

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related DiseasesPMID 33371508Read ↗

Senescent Cells in Cancer: Wanted or Unwanted CitizensSemantic proximity Read ↗

The Contribution of Physiological and Accelerated Aging to Cancer Progression Through Senescence-Induced InflammationSemantic proximity Read ↗

Targeting senescent cells: approaches, opportunities, challengesSemantic proximity Read ↗

Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Diseases.Semantic proximity Read ↗

Senescent cells and their secretory phenotype as targets for cancer therapy.Semantic proximity Read ↗

Senescence and senolysis in cancer: The latest findingsSemantic proximity Read ↗

[Involvement of phenotype secretor of senescent cells in the development of cancer, aging and the diseases associated with age].Semantic proximity Read ↗

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.Semantic proximity Read ↗

Therapeutic strategies targeting cellular senescence for cancer and other diseasesSemantic proximity Read ↗

From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes.Semantic proximity Read ↗

Senescent Cells in Cancer Therapy: Friends or Foes?Semantic proximity Read ↗

Targeting cellular senescence with senotherapeutics: senolytics and senomorphicsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.