Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deciphering the mechanism for induction of senescence-associated secretory phenotype (SASP) and its role in ageing and cancer development

10 Jul 2019

Abstract excerpt

Cellular senescence is an irreversible form of cell cycle arrest that can be induced by persistent DNA damage, and is well known to function as an important tumour suppression mechanism. Cellular senescence is detected in aged organisms; thus, it is also recognized as a hallmark of organismal ageing. Unlike apoptotic cells, senescent cells can survive for long periods of time. Recently, it has been shown that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to interferon and immune responses
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31297533
DOI: 10.1093/jb/mvz055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deciphering the mechanism for induction of senescence-associated secretory phenotype (SASP) and its role in ageing and cancer developmentPMID 31297533Read ↗

Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases.Semantic proximity Read ↗

[Involvement of phenotype secretor of senescent cells in the development of cancer, aging and the diseases associated with age].Semantic proximity Read ↗

From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes.Semantic proximity Read ↗

Senescent cells and their secretory phenotype as targets for cancer therapy.Semantic proximity Read ↗

Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype.Semantic proximity Read ↗

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related DiseasesSemantic proximity Read ↗

The senescence-associated secretory phenotype and its physiological and pathological implications.Semantic proximity Read ↗

Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer.Semantic proximity Read ↗

Senescent Cells in Cancer: Wanted or Unwanted CitizensSemantic proximity Read ↗

Cell senescence, the senescence-associated secretory phenotype, and cancers.Semantic proximity Read ↗

Cellular senescence: mechanisms and relevance to cancer and agingSemantic proximity Read ↗

The Contribution of Physiological and Accelerated Aging to Cancer Progression Through Senescence-Induced InflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.