Article
[Involvement of phenotype secretor of senescent cells in the development of cancer, aging and the diseases associated with age].
Gaceta medica de Mexico - 1 Jan 2000
González-Puertos Viridiana Yazmín, Maciel-Barón Luis Ángel, Barajas-Gómez Bertha Alicia, López-Diazguerrero Norma Edith, Königsberg Mina
Abstract excerpt
Cellular senescence is defined as the physiological program of terminal growth arrest; in mammals it is an important tumor-suppressor mechanism since it stops premalignant cell proliferation. However, senescence also contributes to the decline associated to aging and the development of several diseases. This is explained by the fact that senescent cells secrete diverse molecules, which compromise the cellular...
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