Article
Interruption of G protein-coupling in CXCR2 does not alter ligand binding, but eliminates ligand-activation of GTPgamma35S binding, calcium mobilization, and chemotaxis.
Biochemistry - 9 Dec 1997
Yang W, Schraw W P, Mueller S G, Richmond A
Abstract excerpt
CXCR2 is a seven-transmembrane receptor that transduces intracellular signals in response to the chemokines IL-8, MGSA/GRO, and other ELR motif-containing CXC chemokines by coupling to heterotrimeric GTP-binding proteins. In this study, we have mutated two putative G protein-coupling regions of C...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.