Article
Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation.
Science signaling - 21 Mar 2017
Ziarek Joshua J, Kleist Andrew B, London Nir, Raveh Barak, Montpas Nicolas, Bonneterre Julien, St-Onge Geneviève, DiCosmo-Ponticello Crystal J, Koplinski Chad A, Roy Ishan, Stephens Bryan, Thelen Sylvia, Veldkamp Christopher T, Coffman Frederick D, Cohen Marion C, Dwinell Michael B, Thelen Marcus, Peterson Francis C, Heveker Nikolaus, Volkman Brian F
Abstract excerpt
Chemokines orchestrate cell migration for development, immune surveillance, and disease by binding to cell surface heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs). The array of interactions between the nearly 50 chemokines and their 20 GPCR targets generates an extensive signaling network to which promiscuity and biased agonism add further complexity. The receptor CXCR4...
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