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Article

The negative charge of the 343 site is essential for maintaining physiological functions of CXCR4.

BMC molecular and cell biology - 23 Jan 2021

Wang Liqing, Xiong Qiuhong, Li Ping, Chen Guangxin, Tariq Nayab, Wu Changxin

Abstract excerpt

BACKGROUND: Warts, hypogammaglobulinemia, recurrent bacterial infections and myelokathexis (WHIM) syndrome is a primary immunodeficiency disease (PID) usually caused by autosomal dominant mutations in the chemokine receptor CXCR4 gene. To date, a total of nine different mutations including eight truncation mutations and one missense mutation (E343K, CXCR4E343K) distributed in the C-terminus of CXCR4 have been...

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Identifiers

PMID: 33485325
DOI: 10.1186/s12860-021-00347-9
PMCID: PMC7825245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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