Article
Nonlinear Radiation-Induced Cataract Using the Radiosensitive Ptch1(+/-) Mouse Model.
Radiation research - 1 Sept 2016
De Stefano Ilaria, Giardullo Paola, Tanno Barbara, Leonardi Simona, Pasquali Emanuela, Babini Gabriele, Saran Anna, Mancuso Mariateresa
Abstract excerpt
While most of the evidence for radiation-induced late health effects relates to cancer, there has been increasing interest recently in the development of non-cancer diseases, including lens opacity, observed in populations exposed to low-dose radiation. In a recent study, we reported that mice heterozygous for the Patched1 (Ptch1) gene represented a novel and powerful animal model for this disorder, and a useful...
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