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Article

Ptc1 heterozygous knockout mice as a model of multi-organ tumorigenesis.

Cancer letters - 28 Mar 2006

Pazzaglia Simonetta

Abstract excerpt

Mutations in the Ptc1 gene are responsible for basal cell nevus (BCN) syndrome, and are commonly found in sporadic basal cell carcinomas (BCC) and in medulloblastoma (MB). Ptc1 hemizygosity in mice underlies this model's susceptibility to multi-organ tumorigenesis. Similar to BCN syndrome patients, the Ptc1 mouse model is characterized by tumor predisposition and radiation hypersensitivity. Ptc1(+/-) mice develop...

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Source

Identifiers

PMID: 15925443
DOI: 10.1016/j.canlet.2005.03.047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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