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Article

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome.

Nature medicine - 1 May 1998

Hahn H, Wojnowski L, Zimmer A M, Hall J, Miller G, Zimmer A

Abstract excerpt

Gorlin (or nevoid basal cell carcinoma) syndrome is characterized by a variety of clinical problems including generalized overgrowth of the body, cysts, developmental abnormalities of the skeleton and a predisposition to benign and malignant tumors. The syndrome results from germline mutations of the human homolog of the drosophila segment polarity gene patched (ptc). Here we report that mice heterozygous for ptc...

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PMID: 9585239
DOI: 10.1038/nm0598-619

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Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome.PMID 9585239Read ↗

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Genetics of basal cell carcinoma.Semantic proximity Read ↗

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Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.Semantic proximity Read ↗

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