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Article

A mechanistic model for medulloblastoma induction in mice.

Radiation research - 1 May 2013

Heidenreich W F, Saran A, Atkinson M, Pazzaglia S

Abstract excerpt

Medulloblastomas in Patched heterozygous mice (Ptc1(+/-) mice) are induced with high probability by ionizing radiation applied in the immediate post-natal period. A mathematical model is described here that accommodates the dependence of the medulloblastoma incidence on dose, age at exposure and age. The model assumes that the first step in the development of the cancer is already present in all cells of the...

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Source

Identifiers

PMID: 23560628
DOI: 10.1667/RR3130.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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