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Article

Modulation of patched-associated susceptibility to radiation induced tumorigenesis by genetic background.

Cancer research - 1 Jun 2004

Pazzaglia Simonetta, Mancuso Mariateresa, Tanori Mirella, Atkinson Michael J, Merola Paola, Rebessi Simonetta, Di Majo Vincenzo, Covelli Vincenzo, Hahn Heidi, Saran Anna

Abstract excerpt

We described previously a basal cell carcinoma (BCC) and medulloblastoma (MB) phenotype for CD1Ptch1(neo67/+) mice exposed to ionizing radiation. Ptch1 heterozygous mice mimic the predisposition to BCC and MB development of patients affected by nevoid BCC syndrome that inherit a mutant Patched (Ptch1) allele. To examine the impact of genetic background on development of BCCs and other tumors we used two outbred...

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PMID: 15172986
DOI: 10.1158/0008-5472.CAN-03-3716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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