Article
The Patched 1 tumor-suppressor gene protects the mouse lens from spontaneous and radiation-induced cataract.
The American journal of pathology - 1 Jan 2015
De Stefano Ilaria, Tanno Barbara, Giardullo Paola, Leonardi Simona, Pasquali Emanuela, Antonelli Francesca, Tanori Mirella, Casciati Arianna, Pazzaglia Simonetta, Saran Anna, Mancuso Mariateresa
Abstract excerpt
Age-related cataract is the most common cause of visual impairment. Moreover, traumatic cataracts form after injury to the eye, including radiation damage. We report herein that sonic hedgehog (Shh) signaling plays a key role in cataract development and in normal lens response to radiation injury. Mice heterozygous for Patched 1 (Ptch1), the Shh receptor and negative regulator of the pathway, develop spontaneous...
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