p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis.

doi:10.1038/ng0994-66

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Article

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis.

Nature genetics - 1 Sept 1994

Kemp C J, Wheldon T, Balmain A

Abstract excerpt

Mice constitutively lacking alleles of the p53 tumour suppressor gene spontaneously develop lymphomas and sarcomas. We report here that a single dose of 4 Gy radiation dramatically decreases the latency for tumour development in p53 heterozygous mice. The pattern of genetic alterations at the rem...

Topics

Animals
Genes, p53
Heterozygote
Lymphoma
Mice
Models, Biological
Mutation
Neoplasms, Radiation-Induced
Sarcoma, Experimental
Time Factors

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