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Article

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis.

Nature genetics - 1 Sept 1994

Kemp C J, Wheldon T, Balmain A

Abstract excerpt

Mice constitutively lacking alleles of the p53 tumour suppressor gene spontaneously develop lymphomas and sarcomas. We report here that a single dose of 4 Gy radiation dramatically decreases the latency for tumour development in p53 heterozygous mice. The pattern of genetic alterations at the remaining wild type allele in these tumours differs substantially from spontaneous tumours from similar mice indicating...

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Identifiers

PMID: 7987394
DOI: 10.1038/ng0994-66

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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