Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Basal cell carcinoma and its development: insights from radiation-induced tumors in Ptch1-deficient mice.

Cancer research - 1 Feb 2004

Mancuso Mariateresa, Pazzaglia Simonetta, Tanori Mirella, Hahn Heidi, Merola Paola, Rebessi Simonetta, Atkinson Michael J, Di Majo Vincenzo, Covelli Vincenzo, Saran Anna

Abstract excerpt

Loss-of-function mutations in Patched (Ptch1) are implicated in constitutive activation of the Sonic hedgehog pathway in human basal cell carcinomas (BCCs), and inherited Ptch1 mutations underlie basal cell nevus syndrome in which a typical feature is multiple BCC occurring with greater incidence in portals of radiotherapy. Mice in which one copy of Ptch1 is inactivated show increased susceptibility to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Basal Cell
Share to Hedgehog Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to Neoplasms, Radiation-Induced

Share to Patched-1 Receptor

Share to Patched Receptors

Share to X-Rays

Source

Identifiers

PMID: 14871823
DOI: 10.1158/0008-5472.can-03-2460

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Basal cell carcinoma and its development: insights from radiation-induced tumors in Ptch1-deficient mice.PMID 14871823Read ↗

Modulation of patched-associated susceptibility to radiation induced tumorigenesis by genetic background.Semantic proximity Read ↗

Patched1 Functions as a Gatekeeper by Promoting Cell Cycle ProgressionSemantic proximity Read ↗

Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice.Semantic proximity Read ↗

Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1.Semantic proximity Read ↗

Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.Semantic proximity Read ↗

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours.Semantic proximity Read ↗

Patched Knockout Mouse Models of Basal Cell CarcinomaSemantic proximity Read ↗

DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice.Semantic proximity Read ↗

Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in Ptch(+/-) mice.Semantic proximity Read ↗

Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice.Semantic proximity Read ↗

Ptc1 heterozygous knockout mice as a model of multi-organ tumorigenesis.Semantic proximity Read ↗

Genetic background modulates gene expression profile induced by skin irradiation in ptch1 mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.