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Article

Detrimental effects of melanocortin-1 receptor (MC1R) variants on the clinical outcomes of BRAF V600 metastatic melanoma patients treated with BRAF inhibitors.

Pigment cell & melanoma research - 1 Nov 2016

Guida Michele, Strippoli Sabino, Ferretta Anna, Bartolomeo Nicola, Porcelli Letizia, Maida Immacolata, Azzariti Amalia, Tommasi Stefania, Grieco Claudia, Guida Stefania, Albano Anna, Lorusso Vito, Guida Gabriella

Abstract excerpt

Melanocortin-1 receptor (MC1R) plays a key role in skin pigmentation, and its variants are linked with a higher melanoma risk. The influence of MC1R variants on the outcomes of patients with metastatic melanoma (MM) treated with BRAF inhibitors (BRAFi) is unknown. We studied the MC1R status in a cohort of 53 consecutive BRAF-mutated patients with MM treated with BRAFi. We also evaluated the effect of vemurafenib...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Kinase Inhibitors

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Share to Receptor, Melanocortin, Type 1

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Source

Identifiers

PMID: 27540956
DOI: 10.1111/pcmr.12516

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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