Associations of MC1R Genotype and Patient Phenotypes with BRAF and NRAS Mutations in Melanoma.

doi:10.1016/j.jid.2017.07.832

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Article

Associations of MC1R Genotype and Patient Phenotypes with BRAF and NRAS Mutations in Melanoma.

The Journal of investigative dermatology - 1 Dec 2017

Thomas Nancy E, Edmiston Sharon N, Kanetsky Peter A, Busam Klaus J, Kricker Anne, Armstrong Bruce K, Cust Anne E, Anton-Culver Hoda, Gruber Stephen B, Luo Li, Orlow Irene, Reiner Anne S, Gallagher Richard P, Zanetti Roberto, Rosso Stefano, Sacchetto Lidia, Dwyer Terence, Parrish Eloise A, Hao Honglin, Gibbs David C, Frank Jill S, Ollila David W, Begg Colin B, Berwick Marianne, Conway Kathleen

Abstract excerpt

Associations of MC1R with BRAF mutations in melanoma have been inconsistent between studies. We sought to determine for 1,227 participants in the international population-based Genes, Environment, and Melanoma (GEM) study whether MC1R and phenotypes were associated with melanoma BRAF/NRAS subtypes. We used logistic regression adjusted by age, sex, and study design features and examined effect modifications. BRAF+...

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Identifiers

PMID: 28842324
DOI: 10.1016/j.jid.2017.07.832
PMCID: PMC5701875

Genes

BRAF
NRAS
GEM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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