Article
Melanocortin receptor 1 variants and melanoma risk: a study of 2 European populations.
International journal of cancer - 15 Oct 2009
Scherer Dominique, Nagore Eduardo, Bermejo Justo Lorenzo, Figl Adina, Botella-Estrada Rafael, Thirumaran Ranjit Kumar, Angelini Sabrina, Hemminki Kari, Schadendorf Dirk, Kumar Rajiv
Abstract excerpt
Variation within the melanocortin receptor 1 (MC1R) gene, that influences phenotypic traits and susceptibility to melanoma, is abundant across the populations. We assessed and compared the risk of melanoma in 2 European populations, German and Spanish, by genotyping MC1R variants through direct DNA sequencing from 1,185 melanoma cases and 1,582 controls. The presence of any variant in both populations was...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Child
- Female
- Genetic Variation
- Genetics, Population
- Genotype
- Germany
- Hair Color
- Humans
- Linkage Disequilibrium