Article
MC1R germline variants confer risk for BRAF-mutant melanoma.
Science (New York, N.Y.) - 28 Jul 2006
Landi Maria Teresa, Bauer Jürgen, Pfeiffer Ruth M, Elder David E, Hulley Benjamin, Minghetti Paola, Calista Donato, Kanetsky Peter A, Pinkel Daniel, Bastian Boris C
Abstract excerpt
Germline variants in MC1R, the gene encoding the melanocortin-1 receptor, and sun exposure increase risk for melanoma in Caucasians. The majority of melanomas that occur on skin with little evidence of chronic sun-induced damage (non-CSD melanoma) have mutations in the BRAF oncogene, whereas in melanomas on skin with marked CSD (CSD melanoma) these mutations are less frequent. In two independent Caucasian...
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