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Article

MC1R germline variants confer risk for BRAF-mutant melanoma.

Science (New York, N.Y.) - 28 Jul 2006

Landi Maria Teresa, Bauer Jürgen, Pfeiffer Ruth M, Elder David E, Hulley Benjamin, Minghetti Paola, Calista Donato, Kanetsky Peter A, Pinkel Daniel, Bastian Boris C

Abstract excerpt

Germline variants in MC1R, the gene encoding the melanocortin-1 receptor, and sun exposure increase risk for melanoma in Caucasians. The majority of melanomas that occur on skin with little evidence of chronic sun-induced damage (non-CSD melanoma) have mutations in the BRAF oncogene, whereas in m...

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Source

Identifiers

PMID: 16809487
DOI: 10.1126/science.1127515

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16809487-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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MC1R germline variants confer risk for BRAF-mutant melanoma.PMID 16809487Read ↗

MC1R variants increase risk of melanomas harboring BRAF mutations.Semantic proximity Read ↗

The association between MC1R genotype and BRAF mutation status in cutaneous melanoma: findings from an Australian population.Semantic proximity Read ↗

Histologic and Phenotypic Factors and MC1R Status Associated with BRAF(V600E), BRAF(V600K), and NRAS Mutations in a Community-Based Sample of 414 Cutaneous Melanomas.Semantic proximity Read ↗

Behind the Scene: Exploiting MC1R in Skin Cancer Risk and Prevention.Semantic proximity Read ↗

Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study.Semantic proximity Read ↗

Human Determinants and the Role of Melanocortin-1 Receptor Variants in Melanoma Risk Independent of UV Radiation Exposure.Semantic proximity Read ↗

Germline MC1R status influences somatic mutation burden in melanoma.Semantic proximity Read ↗

A large French case-control study emphasizes the role of rare Mc1R variants in melanoma risk.Semantic proximity Read ↗

MC1R genotypes and risk of melanoma before age 40 years: a population-based case-control-family study.Semantic proximity Read ↗

Melanocortin receptor 1 variants and melanoma risk: a study of 2 European populations.Semantic proximity Read ↗

Relationship between Germline MC1R Variants and BRAF-Mutant Melanoma in a North Carolina Population-Based StudySemantic proximity Read ↗

NRAS and BRAF mutations in cutaneous melanoma and the association with MC1R genotype: findings from Spanish and Austrian populations.Semantic proximity Read ↗

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