Article

Decoding the genetic crosstalk network for cardiometabolic diseases and metabolic traits

2026-01-17

Abstract excerpt

Metabolic malfunctions are commonly observed in cardiometabolic diseases (CMDs), yet their genetic connections are not fully explored. We leverage multi-omics to decode the genetic crosstalk between 17 cardiometabolic diseases and 16 metabolic traits. Through genomic structural equation modeling, we identify 7 disease clusters anchored on 7 distinct metabolic axes, revealing subtype-specific variants, candidate ge...

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Literature Corpus work: 1a5edf6d-052c-5ffe-bbe1-b4da18b74435
DOI: 10.64898/2026.01.16.26344249

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