Article
Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes.
Circulation - 10 Feb 2015
Yao Chen, Chen Brian H, Joehanes Roby, Otlu Burcak, Zhang Xiaoling, Liu Chunyu, Huan Tianxiao, Tastan Oznur, Cupples L Adrienne, Meigs James B, Fox Caroline S, Freedman Jane E, Courchesne Paul, O'Donnell Christopher J, Munson Peter J, Keles Sunduz, Levy Daniel
Abstract excerpt
BACKGROUND: Cardiovascular disease (CVD) reflects a highly coordinated complex of traits. Although genome-wide association studies have reported numerous single nucleotide polymorphisms (SNPs) to be associated with CVD, the role of most of these variants in disease processes remains unknown. METHODS AND RESULTS: We built a CVD network using 1512 SNPs associated with 21 CVD traits in genome-wide association...
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