Article

Multi-Tissue Profiling Reveals tissue-specific protein regulation and relationships Between Protein Quantitative Trait Loci (pQTLs) and Cardiometabolic Disease

2025-07-04

Abstract excerpt

Integrating genetic data with protein levels, known as protein quantitative trait loci (pQTLs), can enhance our understanding of disease mechanisms and provide actionable insights for drug discovery, by guiding the direction of therapeutic interventions, clarifying mechanisms of action, and predicting potential side effects. However, most pQTL studies have focused on the plasma proteome, overlooking tissue-specifi...

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Literature Corpus work: 79284c55-43a0-570f-a4d2-a139815dda5d
DOI: 10.1101/2025.06.30.662294

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