Article
Genome-wide linkage and association analysis of cardiometabolic phenotypes in Hispanic Americans.
Journal of human genetics - 1 Feb 2017
Hellwege Jacklyn N, Palmer Nicholette D, Dimitrov Latchezar, Keaton Jacob M, Tabb Keri L, Sajuthi Satria, Taylor Kent D, Ng Maggie C Y, Speliotes Elizabeth K, Hawkins Gregory A, Long Jirong, Ida Chen Yii-Der, Lorenzo Carlos, Norris Jill M, Rotter Jerome I, Langefeld Carl D, Wagenknecht Lynne E, Bowden Donald W
Abstract excerpt
Linkage studies of complex genetic diseases have been largely replaced by genome-wide association studies, due in part to limited success in complex trait discovery. However, recent interest in rare and low-frequency variants motivates re-examination of family-based methods. In this study, we investigated the performance of two-point linkage analysis for over 1.6 million single-nucleotide polymorphisms (SNPs)...
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