Article
Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels.
Human genetics - 1 Feb 2015
Hellwege Jacklyn N, Palmer Nicholette D, Mark Brown W, Brown Mark W, Ziegler Julie T, Sandy An S, An Sandy S, Guo Xiuqing, Ida Chen Y-D, Chen Ida Y-D, Taylor Kent, Hawkins Gregory A, Ng Maggie C Y, Speliotes Elizabeth K, Lorenzo Carlos, Norris Jill M, Rotter Jerome I, Wagenknecht Lynne E, Langefeld Carl D, Bowden Donald W
Abstract excerpt
We previously identified a low-frequency (1.1 %) coding variant (G45R; rs200573126) in the adiponectin gene (ADIPOQ) which was the basis for a multipoint microsatellite linkage signal (LOD = 8.2) for plasma adiponectin levels in Hispanic families. We have empirically evaluated the ability of data from targeted common variants, exome chip genotyping, and genome-wide association study data to detect linkage and...
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