Article
Exome Sequencing Identifies Genetic Variants Associated with Circulating Lipid Levels in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (IRASFS).
Scientific reports - 4 Apr 2018
Gao Chuan, Tabb Keri L, Dimitrov Latchezar M, Taylor Kent D, Wang Nan, Guo Xiuqing, Long Jirong, Rotter Jerome I, Watanabe Richard M, Curran Joanne E, Blangero John, Langefeld Carl D, Bowden Donald W, Palmer Nicholette D
Abstract excerpt
Genome-wide association studies have identified numerous variants associated with lipid levels; yet, the majority are located in non-coding regions with unclear mechanisms. In the Insulin Resistance Atherosclerosis Family Study (IRASFS), heritability estimates suggest a strong genetic basis: low-density lipoprotein (LDL, h2 = 0.50), high-density lipoprotein (HDL, h2 = 0.57), total cholesterol (TC, h2 = 0.53), and...
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