Article
Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits.
Nature communications - 11 Apr 2025
Petty Lauren E, Chen Hung-Hsin, Frankel Elizabeth G, Zhu Wanying, Downie Carolina G, Graff Mariaelisa, Lin Phillip, Sharma Priya, Zhang Xinruo, Scartozzi Alyssa C, Roshani Rashedeh, Landman Joshua M, Boehnke Michael, Bowden Donald W, Chambers John C, Mahajan Anubha, McCarthy Mark I, Ng Maggie C Y, Sim Xueling, Spracklen Cassandra N, Zhang Weihua, Preuss Michael, Bottinger Erwin P, Nadkarni Girish N, Loos Ruth J F, Chen Yii-Der Ida, Tan Jingyi, Ipp Eli, Genter Pauline, Emery Leslie S, Louie Tin, Sofer Tamar, Stilp Adrienne M, Taylor Kent D, Xiang Anny H, Buchanan Thomas A, Roll Kathryn, Gao Chuan, Palmer Nicholette D, Norris Jill M, Wagenknecht Lynne E, Nousome Darryl, Varma Rohit, McKean-Cowdin Roberta, Guo Xiuqing, Hai Yang, Hsueh Willa, Sandow Kevin, Parra Esteban J, Cruz Miguel, Valladares-Salgado Adan, Wacher-Rodarte Niels, Rotter Jerome I, Goodarzi Mark O, Rich Stephen S, Bertoni Alain, Raffel Leslie J, Nadler Jerry L, Kandeel Fouad R, Duggirala Ravindranath, Blangero John, Lehman Donna M, DeFronzo Ralph A, Thameem Farook, Wang Yujie, Gahagan Sheila, Blanco Estela, Burrows Raquel, Huerta-Chagoya Alicia, Florez Jose C, Tusie-Luna Teresa, González-Villalpando Clicerio, Orozco Lorena, Haiman Christopher A, Hanis Craig L, Rohde Rebecca, Whitsel Eric A, Reiner Alexander P, Kooperberg Charles, Li Yun, Duan Qing, Lee Miryoung, Correa-Burrows Paulina, Fried Susan K, North Kari E, McCormick Joseph B, Fisher-Hoch Susan P, Gamazon Eric R, Morris Andrew P, Mercader Josep M, Highland Heather M, Below Jennifer E
Abstract excerpt
Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify...
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