Article
Analysis of Whole Exome Sequencing with Cardiometabolic Traits Using Family-Based Linkage and Association in the IRAS Family Study.
Annals of human genetics - 1 Mar 2017
Tabb Keri L, Hellwege Jacklyn N, Palmer Nicholette D, Dimitrov Latchezar, Sajuthi Satria, Taylor Kent D, Ng Maggie C Y, Hawkins Gregory A, Chen Yii-der Ida, Brown W Mark, McWilliams David, Williams Adrienne, Lorenzo Carlos, Norris Jill M, Long Jirong, Rotter Jerome I, Curran Joanne E, Blangero John, Wagenknecht Lynne E, Langefeld Carl D, Bowden Donald W
Abstract excerpt
Family-based methods are a potentially powerful tool to identify trait-defining genetic variants in extended families, particularly when used to complement conventional association analysis. We utilized two-point linkage analysis and single variant association analysis to evaluate whole exome sequencing (WES) data from 1205 Hispanic Americans (78 families) from the Insulin Resistance Atherosclerosis Family Study....
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