Article
A genome-wide linkage and association analysis of imputed insertions and deletions with cardiometabolic phenotypes in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study.
Genetic epidemiology - 1 May 2017
Gao Chuan, Hsu Fang-Chi, Dimitrov Latchezar M, Okut Hayrettin, Chen Yii-Der I, Taylor Kent D, Rotter Jerome I, Langefeld Carl D, Bowden Donald W, Palmer Nicholette D
Abstract excerpt
Insertions and deletions (INDELs) represent a significant fraction of interindividual variation in the human genome yet their contribution to phenotypes is poorly understood. To confirm the quality of imputed INDELs and investigate their roles in mediating cardiometabolic phenotypes, genome-wide association and linkage analyses were performed for 15 phenotypes with 1,273,952 imputed INDELs in 1,024 Mexican-origin...
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