Article
A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules.
The EMBO journal - 1 Jun 1998
Kropshofer H, Vogt A B, Thery C, Armandola E A, Li B C, Moldenhauer G, Amigorena S, Hämmerling G J
Abstract excerpt
In B cells, the non-classical human leukocyte antigens HLA-DO (DO) and HLA-DM (DM) are residents of lysosome-like organelles where they form tight complexes. DM catalyzes the removal of invariant chain-derived CLIP peptides from classical major histocompatibility complex (MHC) class II molecules, chaperones them until peptides are available for loading, and functions as a peptide editor. Here we show that DO...
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