Article
Editing of the HLA-DR-peptide repertoire by HLA-DM.
The EMBO journal - 15 Nov 1996
Kropshofer H, Vogt A B, Moldenhauer G, Hammer J, Blum J S, Hämmerling G J
Abstract excerpt
Antigenic peptide loading of classical major histocompatibility complex (MHC) class II molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II associated Ii peptide) for peptides derived from antigenic proteins. This process is facilitated by the non-classical MH...
Topics
- Amino Acid Sequence
- Antigens, Differentiation, B-Lymphocyte
- Blotting, Western
- HLA-D Antigens
- HLA-DR Antigens
- Histocompatibility Antigens Class II
- Humans
- Kinetics
- Lysine
- Major Histocompatibility Complex
- Mass Spectrometry
- Molecular Sequence Data
- Mutation
- Peptides
- Precipitin Tests
- Tumor Cells, Cultured