Article
Editing of the HLA-DR-peptide repertoire by HLA-DM.
The EMBO journal - 15 Nov 1996
Kropshofer H, Vogt A B, Moldenhauer G, Hammer J, Blum J S, Hämmerling G J
Abstract excerpt
Antigenic peptide loading of classical major histocompatibility complex (MHC) class II molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II associated Ii peptide) for peptides derived from antigenic proteins. This process is facilitated by the non-classical MHC class II molecule HLA-DM (DM) which catalyzes the removal of CLIP. Up to now it has been unclear whether DM releases...
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