Article
HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
Nature structural & molecular biology - 1 Jan 2013
Guce Abigail I, Mortimer Sarah E, Yoon Taejin, Painter Corrie A, Jiang Wei, Mellins Elizabeth D, Stern Lawrence J
Abstract excerpt
Mammalian class II major histocompatibility (MHCII) proteins bind peptide antigens in endosomal compartments of antigen-presenting cells. The nonclassical MHCII protein HLA-DM chaperones peptide-free MHCII, protecting it against inactivation, and catalyzes peptide exchange on loaded MHCII. Another nonclassical MHCII protein, HLA-DO, binds HLA-DM and influences the repertoire of peptides presented by MHCII...
Topics
- Animals
- Antigen Presentation
- Antigen-Presenting Cells
- Binding Sites
- Cell Line
- Crystallography, X-Ray
- Drosophila melanogaster
- HLA-D Antigens
- Humans
- Molecular Chaperones
- Mutation
- Protein Conformation