Article

Tuning DO:DM ratios modulates MHC class II immunopeptidomes

2021-10-06

Abstract excerpt

<h4>ABSTRACT</h4> Major histocompatibility complex class II (MHC-II) antigen presentation underlies a wide range of immune responses in health and disease. However, how MHC-II antigen presentation is regulated by the peptide-loading catalyst HLA-DM (DM), its associated modulator, HLA-DO (DO), is incompletely understood. This is due largely to technical limitations: model antigen presenting cell (APC) systems that...

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Literature Corpus work: 1d8e6640-f1d1-5931-84a0-0a5ac7abf801
DOI: 10.1101/2021.10.05.463141

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