Article
Revisiting nonclassical HLA II functions in antigen presentation: Peptide editing and its modulation.
HLA - 1 Oct 2020
Álvaro-Benito Miguel, Freund Christian
Abstract excerpt
The nonclassical major histocompatibility complex of class II molecules (ncMHCII) HLA-DM (DM) and HLA-DO (DO) feature essential functions for the selection of the peptides that are displayed by classical MHCII proteins (MHCII) for CD4+ Th cell surveillance. Thus, although the binding groove of classical MHCII dictates the main features of the peptides displayed, ncMHCII function defines the preferential loading...
Topics
- Alleles
- Animals
- Antigen Presentation
- HLA-D Antigens
- Histocompatibility Antigens Class II
- Kinetics
- Mice
- Peptides