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Article

HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.

The Journal of experimental medicine - 18 Dec 2000

Chou C L, Sadegh-Nasseri S

Abstract excerpt

DM facilitates formation of high affinity complexes of peptide-major histocompatibility complex (MHC) by release of class II MHC-associated invariant chain peptide (CLIP). This has been proposed to occur through discrimination of complex stability. By probing kinetic and conformational intermediates of the wild-type and mutant human histocompatibility leukocyte antigen (HLA)-DR1-peptide complexes, and examining...

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Source

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Identifiers

PMID: 11120767
DOI: 10.1084/jem.192.12.1697
PMCID: PMC2213500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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