Article
Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells.
Oncotarget - 20 Sept 2016
Menendez Daniel, Lowe Julie M, Snipe Joyce, Resnick Michael A
Abstract excerpt
Diversity within the p53 transcriptional network can arise from a matrix of changes that include target response element sequences and p53 expression level variations. We previously found that wild type p53 (WT p53) can regulate expression of most innate immune-related Toll-like-receptor genes (TLRs) in human cells, thereby affecting immune responses. Since many tumor-associated p53 mutants exhibit...
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