Article

Mutant p53 suppresses innate immune signaling to promote tumorigenesis

2020-03-13

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the p53 tumor suppressor occur very frequently in human cancer. Often, such mutations lead to the constitutive overproduction of mutant p53 (mtp53) proteins, which can exert a cancer-promoting gain-of-function (GOF). We have identified a novel mechanism by which mtp53 controls both cell-autonomous and non-cell autonomous signaling to promote cancer cell survival and suppress tumor i...

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Literature Corpus work: 47749041-84cc-5680-b2d9-1939475d5f38
DOI: 10.1101/2020.03.12.989384

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