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Mutant p53 protects cells from 12-O-tetradecanoylphorbol-13-acetate-induced death by attenuating activating transcription factor 3 induction.

Cancer research - 15 Nov 2006

Buganim Yosef, Kalo Eyal, Brosh Ran, Besserglick Hila, Nachmany Ido, Rais Yoach, Stambolsky Perry, Tang Xiaohu, Milyavsky Michael, Shats Igor, Kalis Marina, Goldfinger Naomi, Rotter Varda

Abstract excerpt

Mutations in p53 are ubiquitous in human tumors. Some p53 mutations not only result in loss of wild-type (WT) activity but also grant additional functions, termed "gain of function." In this study, we explore how the status of p53 affects the immediate response gene activating transcription factor 3 (ATF3) in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-protein kinase C (PKC) pathway. We show that high doses of...

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Identifiers

PMID: 17108111
DOI: 10.1158/0008-5472.CAN-06-0916

Genes

ATF3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutant p53 protects cells from 12-O-tetradecanoylphorbol-13-acetate-induced death by attenuating activating transcription factor 3 induction.PMID 17108111Read ↗

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