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Article

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation.

International journal of molecular sciences - 13 May 2020

Agupitan Arjelle Decasa, Neeson Paul, Williams Scott, Howitt Jason, Haupt Sue, Haupt Ygal

Abstract excerpt

Awareness of the importance of immunity in controlling cancer development triggered research into the impact of its key oncogenic drivers on the immune response, as well as their value as targets for immunotherapy. At the heart of tumour suppression is p53, which was discovered in the context of viral infection and now emerges as a significant player in normal and cancer immunity. Wild-type p53 (wt p53) plays...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32414156
DOI: 10.3390/ijms21103452
PMCID: PMC7278985

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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