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The Wheel of p53 Helps to Drive the Immune System

21 Apr 2023

Abstract excerpt

The p53 tumor suppressor protein is best known as an inhibitor of the cell cycle and an inducer of apoptosis. Unexpectedly, these functions of p53 are not required for its tumor suppressive activity in animal models. High-throughput transcriptomic investigations as well as individual studies have demonstrated that p53 stimulates expression of many genes involved in immunity. Probably to interfere with its...

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PMID: 37108808
DOI: 10.3390/ijms24087645

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